Gary D Lopaschuk Selected Research

Glycogen

10/2014	Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity.
7/2009	High rates of residual fatty acid oxidation during mild ischemia decrease cardiac work and efficiency.
7/2006	AMPK alterations in cardiac physiology and pathology: enemy or ally?
4/2002	Energy metabolism in the hypertrophied heart.

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Gary D Lopaschuk Research Topics

Disease

47	Heart Failure 05/2024 - 07/2002
41	Insulin Resistance 01/2024 - 05/2002
32	Ischemia 01/2024 - 02/2002
27	Obesity 12/2023 - 01/2007
20	Myocardial Ischemia (Ischemic Heart Diseases) 01/2021 - 09/2002
19	Hypertrophy 01/2024 - 01/2002
17	Cardiomegaly (Heart Hypertrophy) 01/2024 - 04/2002
9	Heart Diseases (Heart Disease) 01/2018 - 01/2007
8	Diabetic Cardiomyopathies 03/2024 - 01/2002
8	Fibrosis (Cirrhosis) 01/2024 - 09/2009
7	Body Weight (Weight, Body) 01/2024 - 10/2007
7	Inflammation (Inflammations) 01/2024 - 03/2014
7	Type 2 Diabetes Mellitus (MODY) 01/2023 - 01/2013
6	Hypertension (High Blood Pressure) 12/2023 - 05/2009
6	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 08/2007
6	Reperfusion Injury 11/2021 - 06/2004
6	Cardiomyopathies (Cardiomyopathy) 01/2021 - 01/2002
6	Myocardial Infarction 06/2019 - 09/2002
6	Hypoxia (Hypoxemia) 01/2016 - 01/2006
6	AIDS-Related Complex (ARC) 08/2013 - 10/2007
4	Glucose Intolerance 01/2024 - 01/2008
4	Infarction (Infarctions) 01/2016 - 10/2010
3	Weight Loss (Weight Reduction) 10/2023 - 01/2019
3	Hyperglycemia 01/2022 - 09/2005
3	Left Ventricular Dysfunction 01/2014 - 12/2008
3	Pulmonary Hypertension 03/2013 - 01/2002
2	Neoplasms (Cancer) 01/2021 - 01/2007
2	Right Ventricular Hypertrophy 03/2013 - 01/2010

Drug/Important Bio-Agent (IBA)

81	Fatty Acids (Saturated Fatty Acids)IBA 01/2024 - 01/2002
72	Glucose (Dextrose)FDA LinkGeneric 05/2024 - 01/2002
25	Insulin (Novolin)FDA Link 01/2023 - 05/2002
23	EnzymesIBA 01/2024 - 05/2002
18	Malonyl Coenzyme A (Malonyl CoA)IBA 01/2021 - 09/2002
14	Adenosine Triphosphate (ATP)IBA 02/2024 - 01/2005
14	LipidsIBA 01/2021 - 03/2006
13	Proteins (Proteins, Gene)FDA Link 01/2023 - 04/2002
13	malonyl-CoA decarboxylaseIBA 01/2021 - 12/2005
8	KetonesIBA 05/2024 - 03/2004
8	Pyruvic Acid (Pyruvate)IBA 10/2023 - 12/2005
8	Oxygen (Dioxygen)IBA 01/2017 - 01/2006
8	AMP-Activated Protein KinasesIBA 06/2013 - 06/2004
7	PalmitatesIBA 01/2024 - 03/2004
7	Pyruvate Dehydrogenase Acetyl-Transferring KinaseIBA 12/2023 - 01/2007
7	CarbohydratesIBA 01/2022 - 03/2004
7	Oxidoreductases (Dehydrogenase)IBA 01/2019 - 12/2005
7	Angiotensin IIIBA 04/2014 - 09/2006
6	Triglycerides (Triacylglycerol)IBA 06/2014 - 05/2002
6	Lactic Acid (Lactate)FDA LinkGeneric 09/2013 - 05/2004
6	LeptinIBA 11/2011 - 03/2006
5	CeramidesIBA 06/2015 - 10/2010
4	salicylhydroxamic acid (SHAM)IBA 05/2024 - 09/2008
4	AdiponectinIBA 01/2024 - 08/2007
4	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 12/2008
4	Branched-Chain Amino AcidsIBA 11/2021 - 11/2018
4	Trimetazidine (Vastarel)IBA 01/2016 - 08/2003
4	AcidsIBA 01/2016 - 05/2002
4	GlycogenIBA 10/2014 - 04/2002
4	Acetyl-CoA CarboxylaseIBA 08/2014 - 05/2002
4	Carnitine (L-Carnitine)FDA LinkGeneric 12/2013 - 04/2002
3	TransferasesIBA 03/2024 - 01/2012
3	Coenzyme A (CoA)IBA 03/2024 - 08/2010
3	CollagenIBA 01/2024 - 09/2009
3	CalciumIBA 01/2022 - 03/2004
3	Angiotensin-Converting Enzyme 2IBA 01/2020 - 03/2014
3	Lysine (L-Lysine)FDA Link 12/2016 - 12/2007
3	DiglyceridesIBA 01/2016 - 10/2010
3	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 06/2015 - 01/2002
3	Protein Kinases (Protein Kinase)IBA 06/2015 - 05/2003
3	Serine (L-Serine)FDA Link 06/2015 - 10/2010
3	Protons (Proton)IBA 01/2014 - 05/2003
3	Appetite Depressants (Anorectics)IBA 08/2013 - 06/2011
3	Protein Isoforms (Isoforms)IBA 08/2012 - 07/2010
3	Adenosine Monophosphate (AMP)IBA 05/2012 - 01/2005
3	Nonesterified Fatty Acids (NEFA)IBA 12/2011 - 10/2004
3	Krebs-Henseleit solutionIBA 07/2009 - 03/2004
2	Peptides (Polypeptides)IBA 01/2024 - 01/2019
2	NG-Nitroarginine Methyl Ester (L-NAME)IBA 12/2023 - 05/2009
2	EstersIBA 10/2023 - 12/2020
2	SodiumIBA 02/2022 - 12/2020
2	SymportersIBA 02/2022 - 12/2020
2	Sodium-Hydrogen ExchangersIBA 06/2020 - 01/2011
2	empagliflozinIBA 01/2020 - 10/2018
2	ResveratrolIBA 01/2019 - 10/2013
2	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 01/2019 - 01/2011
2	Glucagon (Glukagon)FDA Link 01/2019 - 01/2013
2	Glucagon Receptors (Glucagon Receptor)IBA 01/2019 - 01/2013
2	AdipokinesIBA 01/2017 - 08/2007
2	AngiotensinsIBA 01/2016 - 07/2012
2	CalreticulinIBA 01/2016 - 01/2013
2	NAD (NADH)IBA 11/2015 - 08/2012
2	Therapeutic UsesIBA 04/2015 - 03/2014
2	Adenine NucleotidesIBA 10/2014 - 07/2009
2	Acetyl Coenzyme A (Acetyl-CoA)IBA 08/2014 - 07/2009
2	Acyl Coenzyme A (Acyl CoA)IBA 06/2014 - 01/2011
2	angiotensin I (1-7)IBA 04/2014 - 03/2014

Therapy/Procedure

20	Therapeutics 01/2022 - 04/2007
4	Ketogenic Diet 05/2024 - 12/2020
3	Ligation 05/2024 - 05/2012
3	Fat-Restricted Diet (Diet, Fat Restricted) 10/2023 - 01/2021
2	Glycemic Control 01/2019 - 06/2014